I'm running Wiggs, CLS, OB, and R2.
Usually, I've run under a Wedge lead: I just like the healing on crits and kills that keeps toons alive and in the fight. And I get slightly better offense. The counterattack with CLS is nice, but a lot of the time, the other team (and mime) are under R2's stealth, so counterattacks don't trigger. When out of stealth, it's 50/50.
But I've noticed for a while that every rebels team I see in arena runs a CLS lead. They can't all be wrong, so maybe I am. Is CLS hands-down the better rebels leader?