Pre-relic was most likely Talzin. Post-relic definitely Asajj. With the introduction of g13, attack power was already increased a good margin. With relics that margin just grew substantially larger. Her lead simply amplifies that even further. Tanks can only mitigate so much damage. Non-tanks are going to melt against well modded attackers, with substantial emphasis on damage.
Ventress, because for me she's harder to fight. I have an easier time with Talzin, because my main counters can prevent revives and heal off plague (Troopers, BH, Sith triumverate). But under Ventress lead, fast Nightsisters can catch up to me with the TM gain, then stunlock me, and prevent me from getting going again with the TM removal.
More difficult to predict what will happen against Ventress lead. When I look through nightsister walls in TW, where I can use my imperial troopers, I always look for Talzin leads, since they are easy targets. When Ventress is leading, characters gain TM as you reduce their health, and that can result in stuff like Daka suddenly getting a couple of stuns off, which can turn the battle. It's also easier to attack Talzin leads, because you can remove the extra plague, by simply making sure that you team has adequate healing.
Asajj lead makes for an easy counter using bugs. Talzin lead makes the geo counter more iffy as spreading plague eats the bugs health and stops their cleanses.
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So all good then.